The United States Coast Guard's Helicopter Interdiction Tactical Squadron and Law Enforcement Detachments use versions of the Barrett M107 to disable the engines of go-fast boats carrying illegal drugs. Barrett M82 rifles have also attracted attention from civilian law enforcement agencies; they have been adopted by the New York City Police Department as well as the Pittsburgh Police. If it becomes necessary to immobilize a vehicle, a .50 BMG round in the engine block will shut it down quickly. If it is necessary to breach barriers, a .50 BMG round will penetrate most commercial brick walls and concrete blocks.

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In October 2012, Chris Masters, a reporter for the Australian The Daily Telegraph, quoted an unnamed source that claimed that an unknown Australian soldier from Delta Company, 2nd Commando Regiment had made a shot at 2,815 m (3,079 yd) using a .50 cal Barrett M82 rifle in Afghanistan. If this shot is confirmed it will have broken the 2,475 m (2,707 yd) record held by Craig Harrison.